Released on = October 9, 2006, 11:53 am

Press Release Author = Debra Thai

Industry = Biotech

Press Release Summary = Calcium (Ca2+) plays a key role in numerous important
physiological processes with the amount of ionized calcium in blood plasma tightly
regulated within a narrow range (Reviewed in Ref 1).

Press Release Body = Calcium homeostasis is finely regulated by Parathyroid Hormone
(PTH), Calcitonin and Vitamin D. Briefly, a decrease in calcium concentration in the
blood, triggers the release of PTH, an 84-amino acid hormone, from the parathyroid
glands. An increase, however, causes the release of Calcitonin, a 32-amino acid
protein from the thyroid parafollicular cells (C-cells). Vitamin D helps in the
absorption of Ca2+ from the intestine.

AnaSpec, a leading provider of integrated proteomics solutions, carries a wide range
of peptide products to support researchers working with Ca2+ metabolism.

PTH (1-34)
· Human, Bovine, and Rat - the amino-terminal PTH (1-34) fragment satisfies the
structural requirements for all known biological activities of parathyroid hormone
PTH(1-84)]2
· Biotinylated, FAM-labeled, and Lys-biotin-labeled - used as probes in studies such
as characterization of parathyroid hormone receptors3,4
Parathyroid Hormone Related Protein (PTHrP)
· 1-34, 1-40, and 7-34 peptide fragments - responsible for most of humoral
hypercalcemia of malignancy (HHM)5
Calcitonin
· Salmon, Human, Eel, and others
· Biotin-labeled and Fluorescein-labeled
Other Calcitonin related peptides:
· CGRPs
· Adrenomedullins

For more information visit www.anaspec.com.

References:
1. Khan, MM. and JP. Desborough, Pharmacology 19, 1 (2005).
2. Stevenson, RW and JA Parsons, J. Endo. 97, 21 (1983).
3. Newman, W. et al. J. Biol. Chem. 264, 16359 (1989).
4. Brennan, DP. and MA. Levine, J. Biol. Chem. 262, 14795 (1987).
5. Broadus, AE. et al. N. Engl. J. Med. 319, 556 (1988).



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