American Peptide Symposium Poster Describes Synthesis of Hydrocarbon-Stapled Peptides

Released on = July 12, 2007, 8:36 am

Press Release Author = AnaSpec Inc.

Industry = Biotech

Press Release Summary = At the 2007 annual conference of the American Peptide
Society, AnaSpec presented a technical poster that described the facile synthesis of
a hydrocarbon-stapled peptide. Asymmetric synthesis of
(S)-Fmoc-α-(2'-pentenyl)-alanine was successfully accomplished via an Ala-Ni
(II)-BPB-complex [3] in three steps with a 40% total yield.

Press Release Body = July 10, 2007 - Montreal, QC, Canada

At the 2007 annual conference of the American Peptide Society, AnaSpec presented a
technical poster that described the facile synthesis of a hydrocarbon-stapled
peptide. Asymmetric synthesis of (S)-Fmoc-α-(2'-pentenyl)-alanine was
successfully accomplished via an Ala-Ni (II)-BPB-complex [3] in three steps with a
40% total yield.

The modified hydrocarbon-stapled peptides are helical, relatively
protease-resistant, and cell-permeable peptides that bind with increased affinity
for its target, and may provide a useful strategy for experimental and therapeutic
modulation of protein-protein
interactions in many signaling pathways.

For more information visit www.anaspec.com

Company Info
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to
pharmaceutical, biotech, and academic research institutions throughout the world.
With a vision for innovation through synergy, AnaSpec focuses on three core
technologies: peptides, detection reagents, and combinatorial chemistry.
Established in 1993, AnaSpec\'s headquarters and manufacturing facilities are located
in San Jose, CA.


Web Site = http://www.anaspec.com

Contact Details = Ping Yang
ping@anaspec.com

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