Released on: February 26, 2008, 5:56 am

Press Release Author: ClinPhone

Industry: Pharmaceuticals

Press Release Summary: A recent poll conducted by ClinPhone, the global leader in
clinical technology solutions, revealed that over 60% of responders are either
currently implementing or considering implementing adaptive trials. The opinion poll
of over 500 participants was part of ClinPhone's educational and interactive webinar
series titled "Applications in Adaptive Trial Designs", delivered in collaboration
with Cytel Inc., a leading provider of clinical trial consulting services. The
results show that the adoption of adaptive techniques is gaining rapid momentum due
to their major benefits including effective selection of optimal dose, accelerating
decision making and shortening drug development timeline.

Press Release Body: A recent poll conducted by ClinPhone, the global leader in
clinical technology solutions, revealed that over 60% of responders are either
currently implementing or considering implementing adaptive trials. The opinion poll
of over 500 participants was part of ClinPhone's educational and interactive webinar
series titled "Applications in Adaptive Trial Designs", delivered in collaboration
with Cytel Inc., a leading provider of clinical trial consulting services. The
results show that the adoption of adaptive techniques is gaining rapid momentum due
to their major benefits including effective selection of optimal dose, accelerating
decision making and shortening drug development timeline.

Adaptive trials are studies that use accumulating clinical response data to decide
how to modify aspects of the study without undermining the validity and integrity of
the trial. Although the use of interim analyses is not new, the option to make
design modifications within a formal framework accepted by regulators is a new
development. The webinar highlighted that successful implementation of such designs
requires selection of optimal methodology based on sound statistical input, robust
trial simulation capability and rapid access to on-going study data.

Graham Nicholls, Product Manager at ClinPhone, comments "We received an overwhelming
response to this webinar topic - with over 500 people attending the event. The
response underscores sponsors' keen interest in ClinPhone's advances in adaptive
trials and thought leadership at the forefront of technology developments.
Technology plays a central role in delivering these types of studies, and ClinPhone
is leading the way in offering integrated solutions to deliver enhanced
functionality required by these complex designs."

Sponsors face a number of unique challenges when implementing an adaptive trial.
They include having to rapidly adjust the randomization procedure to reflect
adaptations, making speedy adjustments to medication supply chain as a result of
such changes, and estimating clinical supply needs before and during the study.
ClinPhone has an unrivalled wealth of experience in providing cutting-edge
technology solutions to enable sponsors to overcome each of these challenges.
ClinPhone's experience covers all of the major types of adaptive trials including
studies involving response adaptive designs, dropping of a treatment arm or dose,
adaptive cohort analysis and sample size modifications.

ClinPhone's flexible and integrated technology solutions in randomization, trial
supply management, EDC and ePRO provide the essential building blocks for effective
and successful adaptive trial implementation. ClinPhone's suite of solutions have
supported over 75 protocols with design adaptations, helping sponsors achieve time
and cost savings while maintaining regulatory standards.


Web Site: http://www.clinphone.com

Contact Details: For further information on ClinPhone's clinical technology
solutions, please visit www.clinphone.com, or alternatively email info@clinphone.com