Scientist Uses Stem Cells To Repair Heart
Released on: July 10, 2010, 6:27 am
Author: Cryo-Cell International, Inc.
Dr. Joshua Hare believes medicine is close to a goal long thought to be impossible: healing the human heart.
The way to get there? Stem cells.
"These could be as big as antibiotics were in the last century," said Hare, who leads the University of Miami 's new Stem Cell Institute. "Stem cells have the potential to have that kind of impact. Diseases like heart attacks, strokes, kidney failure, liver failure — we will be able to transition them into things you live with."
Hare spends his days peering through powerful microscopes, recruiting scientists from top universities and attending to patients betting on improving their conditions through his clinical trials.
Stem cells, only one-thousandth the size of a grain of sand, are the master cells of the body, the source from which all other cells are created.
The most basic are embryonic stem cells, which are "totipotent," meaning they can divide into any other type of cell — heart tissue, brain tissue, kidney tissue — all 220 cells that exist in the human body. They're controversial because when they are harvested, the embryo is destroyed, ending potential life.
But coming into view are new kinds of stem cells — immature adult stem cells that can be extracted from bone marrow, from organs such as the heart or kidney or even from the skin. These can be taken without destroying embryos.
While researchers until recently believed adult stem cells were limited because they could develop only into cells similar to them — bone marrow cells only into cord blood stem cells, for example — evidence is growing that they, too, may become the tissue for hearts, brains, kidneys and other organs.
Hare expounds on these developments:
Q. You've said that the basic idea behind your work is that a healthy human body is creating stem cells all the time to keep its organs healthy, and you're trying to tap into this ability to expand its powers?
A: That's the theory. It does sound fantastic. Actually, it happens in the body all the time, in tiny amounts. In our blood, to survive, we have red blood cells that carry oxygen, white cells that regulate the immune system and platelets, which are tiny cells that seal off cuts. They come from stem cells in the bone marrow. The marrow is the source for all red blood cells, platelets and some white blood cells.
The cells circulate in the blood all the time. Unless there's a signal that says, "Come here and do this," they will just keep circulating. If you get a cut, the cells will be recruited to that area to do what they do.
Q: Could such cells heal a heart attack all by themselves?
A: Experts believe the ability of the body to heal itself without help is limited. The system can slowly replace missing cells here and there, over a lifetime. But it's not designed to repair a massive injury like a heart attack. That's where we as doctors can intervene.
Q: In fact, you are intervening. You've led two studies at Johns Hopkins University and University of Miami in which you have harvested immature, or "mesenchymal" adult cord blood stem cells from the bone marrow, multiplied them many times in the lab, then injected them into the damaged heart. Is the idea that the bone marrow stem cells become heart cells?
A: This is where the biology gets somewhat murky. We don't understand all the elements. We do have evidence that the cells differentiate, develop into healthy heart tissue.
Q: And this could be true with a damaged liver, kidney or brain?
A: In theory.
Q: You've said other kinds of adult stem cells are at work too?
A: Many cells are involved in the body's attempts to heal itself. Some are from blood cells from bone marrow. But also, within the organs themselves, there are resident precursor cells that are stem cells. They're sitting there like front-line soldiers in an injury. We think those stem cell cord blood collections that talk to each other and can go out and do healing. So we are engaging in a new study that will look at cardiac stem cells.
We can take pieces of heart tissue during surgery, multiply the stem cells in the lab and have a large amount to give back to the patient.
Q: Could an organ stem cell from, say, heart tissue, become a stem cell in the brain or kidney?
A: It's possible, but not certain. We're interested in studying how many degrees of freedom these cells have.
Q: And now researchers are getting stem cells even from the skin?
A: We're starting to look at that. We know that stem cells in the skin replenish every 120 days. Researchers a year ago took regular stem cells from the skin and genetically reprogrammed them by introducing four genes. They were able to turn them into stem cells with a nearly unlimited capacity.
The C'elleSM service was introduced in November 2007 as the first and only service that empowers women to collect and cryopreserve menstrual flow containing undifferentiated adult stem cells for future utilization by the donor or possibly their first-degree relatives in a manner similar to umbilical cord blood stem cells. For more information, visit www.celle.com.
About Cryo-Cell International, Inc. (OTCBB: CCEL.OB)
Based in Oldsmar , Florida , with nearly 200,000 clients worldwide, Cryo-Cell is a global leader in stem cell innovation. ISO 9001:2000 certified and accredited by the AABB, Cryo-Cell operates in a state-of-the-art Good Manufacturing Practice and Good Tissue Practice (cGMP/cGTP)-compliant facility. Cryo-Cell is a publicly traded company. OTC Bulletin Board Symbol: CCEL. For more information, please call 1-800-STOR-CELL (1-800-786-7235) or visit www.cryo-cell.com.
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